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Q: Does YFull analyze mtDNA information?

A: Since March 2019 YFull analyzes FASTA files with full mtDNA sequence.

To view YFull's interpretation of your mtDNA, select "mtDNA" > "Hg and SNPs" or "MReport" in the menu on the left side of your account home page. Then, select your YFull identification number and use the "Submit" button to gain access to your mt-Haplogroup and your rCRS and RSRS values. There are several download options.


For constructing the MTree YFull uses data of their customers and data from GenBank The initial version of MTree was based on the PhyloTree 17 of van Oven (18 Feb 2016) . See van Oven M, Kayser M. 2009. Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum Mutat 30(2):E386-E394. PhyloTree.org. doi:10.1002/humu.20921

Also YFull used some information from Ian Logan's website

Formula of calculation of phylogenetic weight of mutation based on HaploGrep principes See Weissensteiner H., Pacher D., Kloss-Brandstätter A., Forer L., Specht G., Bandelt H.-J., Kronenberg F., Salas A., Schönherr S. 2016. HaploGrep 2: mitochondrial haplogroup classification in the era of high-throughput sequencing. Nucl. Acids. Res. 2016 Apr 15; doi:10.1093/nar/gkw233

For the mtDNA haplogroup classification YFull uses Kulczynski distance. See Kloss-Brandstätter A., Pacher D., Schönherr S., Weissensteiner H., Binna R., Specht G., Kronenberg F. 2011. HaploGrep: a fast and reliable algorithm for automatic classification of mitochondrial DNA haplogroups< Hum Mutat. 2011 Jan;32(1):25-32. doi: 10.1002/humu.21382. Epub 2010 Nov 16.

Last updated March 21, 2019.